NRF2 Synergizer (retail or wholesale)

NRF2 Synergizer (retail or wholesale)

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Protandim® Nrf2 Synergizer*

Time to evolve from just taking supplements to biohacking. Clinically proven to reduce oxidative stress in humans by 40% in 30 days.

Give Your Cells a Fighting Chance

The discovery that started it all. One of the leading theories of aging is the oxidative stress theory. It is based on the fact that our cells are constantly bombarded by free radicals (we call the subsequent damage “oxidative stress”). Our bodies naturally produce antioxidants to fight oxidative stress, but our antioxidant production begins to decline in our early twenties. Protandim Nrf2 Synergizer was sculpted to activate the Nrf2 pathway, a pathway responsible for antioxidant production. With peer-reviewed studies conducted by the likes of Harvard, Ohio State, the American Journal of Physiology and many more, Protandim Nrf2 Synergizer has been shown to reduce oxidative stress by 40% in just 30 days.*


  • Helps the body detoxify genes, keeping the master blueprint of the cell’s function intact *
  • Reduces oxidative stress by 40% in just 30 days *
  • Significantly reduces cellular stress through Nrf2 activation *
  • Produces enzymes capable of neutralizing more than 1,000,000 free radicals *
  • Helps to regulate survival genes *
  • Supports the body's natural ability to repair and rejuvenate its own cells 

Protandim Unleashes Powerful Antioxidant Enzymes to Protect Cells

Protandim Nrf2 Synergizer's proprietary formula activates the Nrf2 protein, also known as a “master regulator” of the body’s healthy stress response. Nrf2 Synergizer stimulates this protein, resulting in the body producing its own powerful, protective antioxidant enzymes: superoxide dismutase, heme-oxygenase, glutathione peroxidase and catalase. *

These enzymes function as potent antioxidants capable of neutralizing more than one million free radicals or reactive oxygen species. It’s the synergy of ingredients in Protandim that are effective in activating the Nrf2 pathway. There are other benefits of Nrf2 activation beyond cellular protection. Protandim supports the body's natural cellular repair and rejuvenation and detoxification processes, keeping the master blueprint of the cell’s function intact.

Protandim Nrf2 Synergizer is the only supplement proven in a clinical study to reduce oxidative stress by an average of 40% in 30 days. It has been shown to increase superoxide dismutase levels by 30%, and catalase by 54%. When individuals were supplemented with Protandim Nrf2 Synergizer for 30 days, the age-dependent increase in lipid peroxidation was reduced to the level of a 20-year-old. This supports the scientific premise that the body is not only capable of making its own antioxidant enzymes, but also that their production can be activated by Protandim Nrf2 Synergizer to reduce oxidative stress and support the healthy aging process. *

40 % Reduction in Oxidative Stress in 30 Days*

* These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure or prevent any disease.


Turmeric Root

Turmeric has been used for 4,000 years in both Ayurvedic and Chinese medicine to support good health. Current studies show that turmeric helps fight cellular stress, maintain joint health, and aid digestion. Turmeric is known to contain natural phenols called curcuminoids. *

Green Tea

Green tea is made from unfermented leaves and reportedly contains the highest concentration of powerful antioxidants called polyphenols, particularly catechins, of which epigallocatechin gallate (EGCG) is the most abundant. Protandim’s green tea extract contains 98% polyphenols. Green tea has been traditionally used for many health benefits, including maintaining body temperature and blood sugar levels already in a normal range, promoting digestion, supporting healthy mental processes and cardiovascular health. *


Bacopa has long been hailed for its ability to promote cognitive abilities. Bacopa has been important in Ayurvedic medicine for centuries, used chiefly to enhance clear thinking and memory function. Studies suggest it provides strong cellular defense. It is also used to promote concentration, alertness and focus. The bacopa ingredient in Protandim is high in bacosides, the major constituent of which is the botanical compound called saponins. *

Milk Thistle

Milk thistle has been used for 2,000 years as an herbal remedy to support liver, kidney and gallbladder function. Several scientific studies suggest that substances in milk thistle (especially a flavonoid called silymarin) support healthy detoxification. *


Called the “king of Ayurvedic herbs,” is an adaptogen (a substance that supports the body's ability to accommodate various everyday stressors). Ashwagandha has also been used as a way to support memory enhancement and restful sleep. The primary active components in Ashwagandha are a group of chemical compounds called withanolides. *


Label Info

Serving Size
1 Caplet
Servings Per Container
Amount Per ServingAmountDV% **
Calcium (as dicalcium phosphate and calcium carbonate)77mg8%
Proprietary Blend675mg † 
Milk Thistle Extract (Silybum Marianum) Seed  
Bacopa Extract (Bacopa Monnieri) Whole Herb  
Ashwagandha Extract (Withania Somnifera) Root  
Green Tea Extract (Camellia Sinensis) Leaf  
Turmeric Extract (Curcuma Longa) Rhizome  



Adults take one caplet daily with food.


If you are pregnant, nursing, or on immunosuppressive therapy, please consult with your physician before taking Protandim.


100% Vegetarian. Free of Gluten, Wheat, Dairy, Gelatin and Yeast.

** % Daily value based on a 2,000 calorie diet.
*** Compared to the free radical scavenging capacity of 2g of Vitamin C.

† Daily value not established.
‡ The benefits listed for the above ingredients are based on historical/documented use. Some of these benefits may not be available at their full amounts at the current recommended dose of Protandim. You may have to consume more than one (1) Protandim tablet to get the benefit described above.

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Product Codenrf2

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